The cleaning processes used in our industry rely upon solubilization, chemical reaction and physical
action for residue removal.
It is possible to optimize the solubilization of the drug and still not
achieve clean equipment.
Often the physical action associated with cleaning and the disassembly of
the equipment determine the success of the cleaning process.
A number of variables should be taken into consideration when designing equipment and in the
development and performance of the cleaning process.
These variables include but are not limited to the equipment surface characteristics, equipment geometry, equipment composition, the cleaning
agent, temperature and flow rate of cleaning agents and time of exposure.
For manual procedures, other factors, such as the detailed steps of the cleaning process and operator training, play a large
role. In both manual and automated cleaning, the disassembly of equipment may be necessary for
effective, reproducible cleaning.
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